Angelman Syndrome – Symptoms and Causes

By
Sherry Hight
-

6Causes of Angelman Syndrome

Chromosome Deletions

The majority of Angelman syndrome cases are caused by chromosome deletions. This means an area in the maternal chromosome containing the UBE3A gene is deleted. Studies have shown that genetic microdeletions are basically abnormal processes and not hereditary. Chromosome deletions account for around 70 percent of cases. Among these, about 1 percent of cases have a rearrangement in the deleted chromosome region. More specifically, a part of the maternal chromosome 15 with the UBE3A gene is separated and reattached to another chromosome region. This interferes with the functions of other genetic materials, thus causing the syndrome. [6]

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